A Personalized Healthcare and Wellness Lifestyle management system optimized via each individual's unique genetic profile for better precision and reduction of guesswork. This is delivered by a personalized interactive App with AI and Televideo capabilities that responds to queries in realtime with actionable recommendations compatible with the individual's unique genetics. Additionally, it frees the care providers and their clients from the limitations of geography and time. The integration of multi-disciplinary and multi-domain data that is unique to each individual aims to systematically approach a more "holistic" and also personalized care in contrast to the traditional one-size-fits-all reductionism. This presents a promising glimpse of the new and rapidly growing trend of collaboration between evidence-based medical science, human data science and IT. Application in the area of weight management and to some chronic diseases related to overweight and obesity would be reported.